MULTIPLEXED CRISPR/CAS9-MEDIATED KNOCKOUT OF 19 FANCONI ANEMIA PATHWAY GENES IN ZEBRAFISH REVEALED THEIR ROLES IN GROWTH, SEXUAL DEVELOPMENT AND FERTILITY.

Fanconi Anemia (FA) is a genomic instability syndrome resulting in aplastic anemia, developmental abnormalities, and predisposition to hematological and other solid organ malignancies.Mutations in genes that encode proteins of the FA pathway fail to orchestrate the repair of DNA damage caused by DNA interstrand crosslinks.Zebrafish harbor homologs

Recent technologies have changed the way media of the human being, which shall establish direct contact with many people anywhere in the world.Allied to this fact, there is a virtualization increasing the human person, culminating in an immersion in the virtual world, which ultimately creates an increasing dependence on technology in order Suppleme

Background.The relationship between alcohol dependence and suicidal tendency is well recognized.Self-harm by cut throat is an uncommon but is potentially life-threatening when attempted.We present a description and discussion of a series of three cases of alcohol dependence Pillboxes syndrome who presented with self-inflicted cut throat wounds duri

Microvascular complications of diabetic retinopathy Warming Equipment:Dry/Heated Display Cases (DR) may require surgical intervention in the form of vitrectomy.Since its inception, diabetic vitrectomy has evolved with introduction of better instruments, newer techniques, and smaller port sizes.Common indications for diabetic vitrectomy include nonr

Results of creep tests of two Fe-27 at.% Al-based alloys with additions of 2.7 and 4.8 at.% of niobium conducted in the temperature range from 650 °C to 900 °C in the authors’ laboratory are presented.The purpose of the study is to supplement previous work on Fe-Al-Nb alloys to obtain a more complete overview of creep properties fro